Introduction:

The microchannel photobromination reaction usually generates bromine free radicals from a bromine source (such as hydrogen bromide, N-bromosuccinimide, etc.) under the excitation of light, and then the bromine free radicals react with the organic substrate to introduce bromine atoms into the organic molecule.

Advantages

● Safer: The microchannel reactors have a low total liquid holdup, a large specific surface area, and a high heat transfer efficiency. It can remove a large amount of heat generated by the reaction in time, reduce the risk of reaction.

● More efficient: The fluid in the microchannel is in a highly turbulent state, the reactants are mixed quickly and evenly, make reaction and production more efficient. It will more obvious for some reactions that are limited by mass transfer.

● Better quality: The reaction conditions are easy to accurately control, such as temperature, pressure, material ratio, etc., which can make the reaction proceed in a more stable environment, reduce the occurrence of side reactions, and improve the product purity.

● Greener: Reduce raw material usage and energy consumption, reduce waste acid and the treatment costs, green and Environmentally Friendly.

● Scale-Up: Flexible and versatile system designed for process development, and easy for scale-up process from laboratory research to industrial production.

Process Cases

Procedure

1. Hydrogen peroxide at a flow rate of 1 mL per minute and hydrogen bromide at a flow rate of 1.1 mL per minute are mixed and fed into the CM-DG 6mL device, with the temperature set at 50 °C.

2. Turn on two sets of 395 nm blue light lamp panels. Set M207 to 6 mL per minute, and the above mixture enters the CM-DG-23mL device, and the cooling temperature is -10 °C.

3. After stabilizing for 5 minutes, collect 3 mL of the product. Through HPLC testing, the ratio of the peak areas of M207 and the product is found to be 30 to 68.